About The Honeycomb Study

The Honeycomb Study is studying an investigational drug in children who have GRIN-related Disorder. This initial study will only be recruiting patients with GRIN-related Disorder with a gain-of-function (GoF) variant in GRIN1, GRIN2A, 2GRINB, or GRIN2D. The reason the study is limited to individuals with gain-of-function (GoF) variants is because the investigational radiprodil is designed specifically to decrease the overactive signals being sent out by NMDA receptors caused by gain-offunction (GoF) GRIN variants.

There is no placebo in this study, meaning every child eligible and successfully enrolled will be receiving the investigational radiprodil.

Study Participation

The Honeycomb Study is now enrolling patients!

To be considered for the Honeycomb Study, your child:

  • Must have confirmed gain-of-function (GoF) variant in GRIN1, GRIN2A, GRIN2B, or GRIN2D
  • Must be between 6 months and 12 years of age
  • For patients with seizures:
    • at least 1 observable seizure per week and 4 or more observable seizures during a 4-week observation period
    • seizures did not improve after taking at least 2 anti-seizure medications
  • For patients without qualifying seizures:
    • significant behavioral symptoms

Other eligibility criteria apply. Study participants will receive study-related medical exams and active investigational radiprodil at no cost. If travel is required, a service will help arrange it for you and all reasonable related costs will be covered, to the extent allowable in your country. Children who enroll in this study will be asked to participate for approximately 5 months including both a screening period. During this time, they will be asked to visit the clinic site up to 9 times. Some in-clinic visits may be performed via telephone/home visits for certain patients. Patients may be eligible to for extended dosing in the study or they may enter a follow-up period.

What are clinical trials?

Clinical trials are research studies in which people and their families can volunteer to help find answers to specific health questions. When carefully conducted, they are the safest and fastest way to find new treatments and ways to improve health.

Clinical trials are conducted according to a plan, called a protocol, which describes:

  • the types of patients who may enter the study
  • the schedules of tests and procedures
  • the drug involved
  • what is known about the drug from its prior use in animals or people
  • the dosages, or amount of the drug
  • the length of the study
  • what researchers hope to learn from the study

Volunteers who participate in a study must agree to the rules and conditions outlined in the protocol. Similarly, researchers, doctors, and other health professionals who manage clinical trials must follow strict rules set by the regulatory agencies such as the FDA or EC. These rules make sure that those who agree to participate are treated as safely as possible.

For many people, taking part in a clinical trial is important because their participation helps increase the understanding of diseases and how to treat them. Some other benefits to participation are:

  • Active participation in your child’s health and healthcare
  • Access to healthcare providers who specialize in the condition being studied
  • Knowing that you may be helping others with the condition, as well as your child

Refer A Friend

Do you know a family member or loved one who is diagnosed with GRIN-related Disorder? They may be eligible to participate in the Honeycomb Study. Consider sharing information with their loved ones about how they can participate.

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